Exploratory Study of PD-1 Neoadjuvant Treatment of Recurrent Meningioma (NCT04728568) | Clinical Trial Compass
UnknownNot Applicable
Exploratory Study of PD-1 Neoadjuvant Treatment of Recurrent Meningioma
China15 participantsStarted 2020-06-01
Plain-language summary
This research study is studying a drug as a possible treatment for High Grade Meningioma.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Pathologically diagnosed as a patient with WHO grade III recurrent meningioma
* Age ≥ 18 years
* Kps≥70
* able to accept second surgery
* ECOG Performance Status \< 2
* Glucocorticoid dosage dexamethasone ≤5mg/ day or equivalent dose
Exclusion Criteria:
* Participants who have had chemotherapy, targeted small molecule therapy or study therapy within 14 days of protocol treatment, or those who have not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered more than 2 weeks earlier.
* Participants who are receiving any other investigational agents.
* Participants who have a diagnosis of an immunodeficiency.
* Requires treatment with high dose systemic corticosteroids defined as dexamethasone \>2mg/day or bioequivalent within 7 days of initiating therapy.
* Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent. Unable to undergo brain MRI.