The primary objective of this study is to evaluate the safety, tolerability, and maximum tolerated dose (MTD)/maximum tolerated combination dose (MTCD) or recommended phase 2 dose (RP2D) of AMG 994 as monotherapy and AMG 994 in combination with AMG 404 in participants with advanced solid tumors.
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Number of Participants Who Experienced Dose Limiting Toxicities (DLTs)
Timeframe: Up to Day 28 of Cycle 1 (one cycle = 28 days)
Number of Participants Who Experienced Treatment-emergent Adverse Events (TEAEs)
Timeframe: From first dose of investigational product through 140 days after last dose (AMG 994 or AMG 404, whichever is later), or end of study (whichever is first); median (min, max) duration was 12.5 ( 1.48, 19.32) months.