This is a single-arm prospective trial of an intra- and postoperative topical antiseptic bundle. The study will recruit patients undergoing an open surgical resection of the upper aerodigestive tract requiring a planed vascularized reconstruction, which may be either pedicled and/or free flap. The objectives are to evaluate antimicrobial effects of a perioperative topical antiseptic bundle and to identify the source of surgical site infection as well as the rate of 30-day adverse events in head and neck cancer.
Age range
18 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Oral microbial abundance in preoperative samples measured by quantitative bacteriology.
Timeframe: Baseline (immediately preoperative)
Oral microbial abundance in preoperative samples measured by 16s sequencing.
Timeframe: Baseline (immediately preoperative)
Oral microbial abundance in intraoperative samples prior to antiseptic irrigations measured by quantitative bacteriology.
Timeframe: During surgery before wound irrigation
Oral microbial abundance in intraoperative samples prior to antiseptic irrigations measured by 16s sequencing.
Timeframe: During surgery before wound irrigation
Oral microbial abundance in samples after intraoperative antiseptic irrigations measured by quantitative bacteriology.
Timeframe: During surgery following wound irrigation
Oral microbial abundance in samples after intraoperative antiseptic irrigations measured by 16s sequencing.
Timeframe: During surgery following wound irrigation
Oral microbial abundance in postoperative samples measured by quantitative bacteriology.
Timeframe: Postoperative day 3.
Oral microbial abundance in postoperative samples measured by 16s sequencing.
Timeframe: Postoperative day 3.