This is a single-arm prospective trial of an intra- and postoperative topical antiseptic bundle. The study will recruit patients undergoing an open surgical resection of the upper aerodigestive tract requiring a planed vascularized reconstruction, which may be either pedicled and/or free flap. The objectives are to evaluate antimicrobial effects of a perioperative topical antiseptic bundle and to identify the source of surgical site infection as well as the rate of 30-day adverse events in head and neck cancer.
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Oral microbial abundance in preoperative samples measured by quantitative bacteriology.
Timeframe: Baseline (immediately preoperative)
Oral microbial abundance in preoperative samples measured by 16s sequencing.
Timeframe: Baseline (immediately preoperative)
Oral microbial abundance in intraoperative samples prior to antiseptic irrigations measured by quantitative bacteriology.
Timeframe: During surgery before wound irrigation
Oral microbial abundance in intraoperative samples prior to antiseptic irrigations measured by 16s sequencing.
Timeframe: During surgery before wound irrigation
Oral microbial abundance in samples after intraoperative antiseptic irrigations measured by quantitative bacteriology.
Timeframe: During surgery following wound irrigation
Oral microbial abundance in samples after intraoperative antiseptic irrigations measured by 16s sequencing.
Timeframe: During surgery following wound irrigation
Oral microbial abundance in postoperative samples measured by quantitative bacteriology.
Timeframe: Postoperative day 3.
Oral microbial abundance in postoperative samples measured by 16s sequencing.
Timeframe: Postoperative day 3.