Hard and Soft Tissue Maintenance Around Implants With a Sloped Configuration

Inclusion Criteria: * Written consent after clarification * capability of giving an informed consent * good health as defined by the subjects medical history (no contraindications as described in the exclusion criteria below) * age 18 years of age and over * Good periodontal status: BOP \< 20%, PI \< 30%, no PD \> 4mm * No heavy smokers (\< 10 cigarettes/day) * At least 1 missing tooth in the premolar and molar region (in selected cases in the frontal area) either in the maxilla or in the mandible requiring implant therapy for reconstruction. * implant site must present a buccal bone defect not extending a lingual-buccal or buccal-palatinal height discrepancy of 5mm and a sufficient bone width for simultaneously GBR procedure * implant site must present at least a neighbouring tooth on its mesial aspect Exclusion Criteria: * Insufficient bone volume for implant placement requiring a sinus floor elevation or extensive bone augmentation * Heavy Smokers (\>10 cigarettes/day) * Medication with a contraindication for implant therapy * Skeletal immaturity * Any active malignancy or ongoing treatment for malignancy * An active infection at the operative site * Contraindications to the class of drugs which are used at regular surgical procedures, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, except penicillin-allergy * Pregnancy * unable or unwilling to return for follow-up visits for a period of at least 16 months