Synuclein-One Study

Inclusion Criteria: * Male and female between 40-99 years of age * Prior clinical diagnosis of Parkinson's disease, Multiple System Atrophy, Dementia with Lewy bodies or Pure Autonomic Failure * Health Subjects, no history of clinical or symptoms suggestive with synucleinopathy Exclusion Criteria: * Clinical evidence of severe vascular disease (history of ulceration, poor wound healing, vascular claudication) * Clinically active coronary artery or cerebrovascular disease * Current smoker or alcoholism * History of allergic reaction to local anesthesia for skin biopsies * Use of blood thinners (aspirin or Plavix alone is allowed) * Significantly impaired wound healing or history of scarring or keloid formation * Healthy individuals or individuals with synucleinopathy is disease may be explained by other causes: recent history of encephalitis, Cortical dementia of Alzheimer's type, Whipple's disease, toxin exposure, repeated head injury and stepwise disease progression suggestive of vascular etiology