Active — Not RecruitingNot Applicable

Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies

United States450 participantsStarted 2021-02-19

Plain-language summary

This is a study to evaluate the impact of returning research results that indicate a five-year risk estimate of Alzheimer disease dementia to participants without memory or thinking problems of the Knight Alzheimer Disease Research Center at Washington University in St. Louis.

Who can participate

Age range65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Current Knight ADRC participants who had their clinical assessment in the previous year. * Minimum age of 65 years old * Participant must be classified as cognitively normal (CDR® = 0) at their last clinical assessment. * Participant has either recent research brain MRI and amyloid PET scan results, or recent plasma amyloid measurements (ideally within the past two years, but up to five years will be acceptable due to COVID-19-related delays). * Participant has genetic research results available including APOE status. * Participant is currently consented to be contacted for other research opportunities through the Knight ADRC. Exclusion Criteria: * There are no exclusion criteria, other than not meeting all of the inclusion criteria listed above.

What they're measuring

Change in Geriatric Depression Scale (GDS)

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial. GDS is also measured at the time of informed consent.

Change in Clinical Dementia Rating sum of box score (CDR-SB)

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial.

Change in cognitive composite score

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial.

Trial details

NCT IDNCT04699786

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-10

View on ClinicalTrials.gov More Alzheimer Disease trials

Who can participate

Age range65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Geriatric Depression Scale (GDS)

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial. GDS is also measured at the time of informed consent.

Change in Clinical Dementia Rating sum of box score (CDR-SB)

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial.

Change in cognitive composite score

Timeframe: Based on parent study timeline. Measures are taken 12 months apart and straddle enrollment in trial.