LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138) (NCT04699773) | Clinical Trial Compass
RecruitingNot Applicable
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
United States32 participantsStarted 2021-02-20
Plain-language summary
The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients with radiographic evidence of suggestive of a primary high-grade glioma
✓. Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.
✓. History and physical including neurological exam within 30 days prior to registration
✓. Karnofsky performance status ≥50% within 30 days prior to registration
✓. Age ≥ 18 years old
✓. Patients must have signed an approved informed consent
✓. Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
✓. Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.
Exclusion criteria
✕. Patients that are not surgical candidates for stereotactic biopsy or laser ablation
✕. Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
✕. Infratentorial tumor or evidence of leptomeningeal spread