Multimodal Machine Learning Characterization of Solid Tumors

Inclusion Criteria: * Participants must meet the following criteria on screening examination to be eligible to participate in the study: * Must have primary prostate cancer (e.g. adenocarcinoma of prostate) and deemed a candidate for radical prostatectomy as part of standard clinical care for Cohort A. * Must have evidence or be suspected of having HCC, Glioma and RCC for enrollment in Cohort B. * Age ≥18 years. \--- Because no dosing or adverse event data are currently available on the use of \[18F\]DCFPyL in participants \<18 years of age, children are excluded from this study, but will be eligible for future pediatric trials. * Participants must have adequate kidney function for gadolinium-based contrast administration as assessed by: * estimated or measured glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 for repeated administrations. * a single dose will be administered to subjects with a GFR between 30-60 mL/min/1.73 m2. Investigators will not repeat the gadolinium-based contrast agent administration until the renal function improves and the GFR is higher than 60 cc/min/1.73 m2. These subjects will not undergo examinations on consecutive days even if the renal function improves. * Patient must be able to undergo MRI and PET scans. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * History of allergic reactions attributed to compounds of similar chemical or biologic composition to t…