CompletedPhase 1

Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

United States20 participantsStarted 2021-08-26

Plain-language summary

The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose which is given intravenously (IV).

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing upper extremity reconstruction by a single surgeon. * Surgical cases will include: * Trapeziectomy/suspensionplasty. * PIPJ/MPJ arthroplasty. * Proximal row carpectomy. * Distal ulnar resection. * Distal radius fracture fixation. Exclusion Criteria: * Inability to adequately cannulate a superficial vein in the upper extremity within 5 minutes of tourniquet inflation. * Evidence of subcutaneous extravasation in Bier block group. * History of renal dysfunction. * Vancomycin allergy. * ASA\>/= 3. * History of lung cancer. * Known HIV infection. * History of organ transplantation.

What they're measuring

Tissue concentrations of vancomycin

Timeframe: Approximately 45-60 minutes after skin incision

Trial details

NCT IDNCT04673877

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-08-17

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