To Evaluate the Efficacy and Safety of Anlotinib Combined With Furmonertinib Mesylate in Lung Cancer (NCT04671303) | Clinical Trial Compass
CompletedPhase 2
To Evaluate the Efficacy and Safety of Anlotinib Combined With Furmonertinib Mesylate in Lung Cancer
China36 participantsStarted 2021-01-01
Plain-language summary
This Study is To Evaluate the Efficacy and Safety of Anlotinib Hydrochloride Capsule Combined with Furmonertinib Mesylate in First-line Treatment of Advanced no-squamous and No-small Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
✓. Age 18 and above; Eastern Cooperative Oncology Group Physical condition: 0\~1; The expected survival time is more than 3 months;
✓. The previous report confirmed the presence of an EGFR gene exon 19 deletion mutation or exon 21 L858R mutation, and the investigator verified that the report reflects the patient's current genetic status.
✓. There is at least one measurable lesion other than brain lesion defined by Response Evaluation Criteria In Solid Tumors 1.1 standard;
✓. The main organs are functioning well,Adequate laboratory indicators.
✓. Women of childbearing age should agree to use contraceptives during the study period and for a period of six months after the study; Negative serum or urine pregnancy test within 7 days prior to study inclusion, and must be non-lactating; Male patients should agree to use contraception during the study period and for six months after the end of the study period;
✓. Patients voluntarily participated in this study, signed informed consent, and had good compliance.
Exclusion criteria
✕. Prior history of targeted Epidermal Growth Factor Receptor therapy and anti-angiogenic drugs
✕. Received chemical or biological drugs after the diagnosis of advanced stage;
✕. Subjects had undergone surgery , radiation therapy or other anticancer therapies within 4 weeks prior to the commencement of study treatment; Subjects who have previously received local radiation therapy may be enrolled if the following conditions are met: more than 4 weeks after the end of radiation therapy ;
What they're measuring
1
Safety and Efficacy of drug therapy
Timeframe: up to 4 weeks
Trial details
NCT IDNCT04671303
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
✕. Within 2 weeks before the start of the study, patients were treated with Chinese medicines
✕. Imaging shows that the tumor has invaded the periphery of important blood vessels or the investigator has determined that the tumor is very likely to invade important blood vessels and cause fatal bleeding during the follow-up study.