Study of Oral Idebenone to Treat Non-Alcoholic Steatohepatitis

Inclusion Criteria: * 1\) Male or non-pregnant/ non-lactating women ≥ 18 years of age * 2\) Diagnosis of NASH: NAFLD activity score (NAS) of 4 or greater with a score of 1 for each of the following (steatosis scored 0-3, lobular inflammation scored 0-3, ballooning scored 0-2): * Steatosis * Lobular inflammation * Hepatocyte ballooning 3) Fibrosis (Ishak fibrosis score ≥1 on liver biopsy) within 6 months of enrollment with MELD\<10, or based on MRE Exclusion Criteria: * Presence of any other form of liver disease, including viral hepatitis, autoimmune hepatitis, alcoholic liver disease, genetic causes of chronic liver disease): * Subjects with other etiologies of chronic liver disease, such as chronic hepatitis B and C; autoimmune hepatitis; and inherited liver disease. * ALT\>300 U/l * Total serum bilirubin ≥ to 1.3 mg/dL (Gilbert's Syndrome patients excepted) * International Normalized Ratio (INR) ≥ 1.3 * MELD\>10 * Serum creatinine \>2.0mg/dl * Known alcohol abuse or alcohol use disorder: * \>20 g/day for women * \>30 g/day for men * Active substance abuse * Any medical condition that prevents MRE, MR-PDFF * Platelet count ≤100//mm3 * Decompensated cirrhosis * Hemoglobin \<11 g/dl in females or \<12 g/dl in males * Presence/history of HCC * History of liver transplantation * History of bariatric surgery * History of inflammatory bowel disease * History of cardiovascular disease, long QT syndrome. * Subjects who have participated in investigational drug trials…