Stopped: Permanently closed 11/19/201. The widespread availability of COVID vaccination, the projected decline in infection rates, and the increasing use of non-ibrutinib containing BTKi therapy, we have not been able to get support for this study
This phase II trial studies the effects of ibrutinib in treating patients with B-cell malignancies who are infected with COVID-19. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ibrutinib is a first in class Bruton tyrosine kinase inhibitor (BTKi), for the treatment of B-cell malignancies. This study is being done to determine if taking ibrutinib after contracting COVID-19 will make symptoms better or worse.
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Proportion of patients who require hospitalization for their COVID-19 disease or die (Cohort 1)
Timeframe: Up to 28 days after study registration
Proportion of patients who require mechanical ventilation and/or die (Cohort 2)
Timeframe: Up to 28 days after study entry