CompletedNot Applicable

PCR Cycle Threshold Values and COVID-19 Outcomes

United Kingdom934 participantsStarted 2020-11-24

Plain-language summary

This is a retrospective observational study. The study will use high quality, reliable data that has already been collected for the ISARIC 4C COVID-19 study in order to analyse the relation between predictor variables (laboratory polymerase chain reaction \[PCR\] cycle threshold \[Ct\] values) and outcomes for COVID-19 disease within a hospitalised population.

Who can participate

SexALL

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Inclusion criteria

✓. Adult (aged 18 years and over) patients presenting to UHNM with confirmed SARS-CoV-2 infection AND who are enrolled onto the ISARIC COVID-19 study.
✓. Patients who have undergone an initial diagnostic or screening test for SARS-CoV-2 (from an upper respiratory tract sample) AND a cycle threshold (Ct) value is available on the UHNM laboratory database.

Exclusion criteria

✕. Paediatric patients (under 18 years).
✕. Patients without a PCR Ct result on the UHNM laboratory database
✕. Patients without confirmed SARS-CoV-2 infection
✕. Patients who were not enrolled in to the ISARIC COVID-19 study

What they're measuring

Determine if there is an inverse correlation with risk of poor outcome including admission to intensive care; mechanical ventilation and 28-day mortality.

Timeframe: 01/02/2020 to 01/07/2020

Trial details

NCT IDNCT04651413

SponsorUniversity Hospitals of North Midlands NHS Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-03-31

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