Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition

Inclusion Criteria: * Subject is healthy, as determined by screening evaluation that is not greater than 60 days before the first study visit. * Subject is male or female between 18 and 65 years of age, inclusive. * Subject is an acceptable candidate for venipuncture. * Subject is willing to stop all non-routine OTC medications, as well as vitamins, dietary supplements, and herbals, for 24 hours prior to study drug administration and during pharmacokinetic study visits. Exclusion Criteria: * Subject has a significant medical disease (including cardiovascular, pulmonary, hematologic, endocrine, immunologic, neurologic, renal, gastrointestinal, metabolic, or psychiatric). * Subject has a clinically significant history or presence of any clinically significant gastrointestinal pathology (e.g. chronic diarrhea, inflammatory bowel diseases), unresolved gastrointestinal symptoms (e.g. diarrhea, vomiting), liver or kidney disease, or other conditions known to interfere with the absorption, distribution, metabolism or excretion of study drugs. * Subject has a history of liver or gallbladder disease, or history of myopathy * Subject has a history of angioedema either with or without previous treatment with an angiotensin converting enzyme inhibitor. * Subject was previously diagnosed with diabetes, or treated with antidiabetic agents * Subject has a history of alcohol or drug abuse, which in the opinion of the PI or medical physician, could jeopardize the subject's health or would …