Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft

Inclusion Criteria: * • Nasal septal perforation of a medium size (diameter 0.5 to 2.0 cm), measured by endoscopy * Age above or equal to 18 years * Informed Consent as documented by signature * Patient is willing and able to give written informed consent to participate in the study and to comply with all study requirements, including attending all follow-up visits and assessments Exclusion Criteria: * • Nasal septal perforation of a small (\<0.5 cm) or large size (\>2.0 cm) * Patient is smoking * Known or suspected non-compliance, drug (especially cocaine) or alcohol abuse * Evidence of infection with HIV or hepatitis B or C, syphilis. Patients with a cured hepatitis B or C infection and/or verified antibodies are not excluded. * Known allergies to porcine collagen, penicillin or streptomycin * Women who are pregnant or breast feeding * Intention to become pregnant during the course of the study * Chronic treatment with steroids or immunomodulatory drugs * Diabetes * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Patient is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol or in a dependency or employment with the sponsor. * Patient is unable to understand the patient information * Patient has a known systemic connective tissu…