Efficacy of Secukinumab Compared to Ustekinumab in Adults With Active Psoriatic Arthritis and Failure of TNFα-Inhibitor Treatment

Key Inclusion Criteria: * Diagnosis of PsA as classified by CASPAR criteria for at least 6 months before randomization. * Active PsA at baseline defined as ≥ 3 tender joints out of 68 and ≥ 3 swollen joints out of 66 (dactylitis of a digit counts as one joint each). * Inadequate response or intolerance to previous or current treatment with at least one TNFα inhibitor * Inadequate response or intolerance to conventional disease modifying anti-rheumatic drugs (cDMARDs) * Diagnosis of active plaque psoriasis, with at least one psoriatic plaque of ≥ 2 cm diameter and/or nail changes consistent with psoriasis and/or documented history of plaque psoriasis. * Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies negative at screening. Key Exclusion Criteria: * Pregnant or nursing women, * Previous exposure to secukinumab, ustekinumab or any other biologic drug directly targeting IL-17, IL-17 receptor, IL-12 or IL-23. * Patients for whom the use of secukinumab or ustekinumab is contraindicated. * Use of any other investigational drug. Previous treatment with any cell-depleting therapies including but not limited to anti-CD20 or investigational agents * Evidence of ongoing infectious or malignant process * Subjects receiving high potency opioid analgesics * Ongoing use of prohibited psoriasis treatments/medications Other protocol-defined inclusion/exclusion criteria may apply