End-range Mobilization on Time Curve of Pressure Pain Threshold

Inclusion Criteria: * the clinical classification criteria of knee OA according to the American College of Rheumatology * Categorization of patients as End Of Range Problem based on manual therapy * unilateral/bilateral symptomatic tibiofemoral knee osteoarthritis with radiographic evidence of Kellgren-Lawrence scale between 1 and 3 * pain during weight-bearing activities at least within 6 months * sufficient mental status Exclusion Criteria: * acute inflammation of the knee * class II. obesity (body mass index, BMI\>35kg/m2) * severe degenerative lumbar spine disease (e.g. spondylolisthesis) * systemic inflammatory arthritic or neurological condition * physiotherapy/balneotherapy attendance or manual therapy within 3 months * intraarticular injections in the prior 12 months * use of walking aids * contraindication for manual therapy * complex regional pain syndrome * cognitive impairment