Biomarkers of Endometrial Receptivity (NCT04619524) | Clinical Trial Compass
RecruitingNot Applicable
Biomarkers of Endometrial Receptivity
Czechia476 participantsStarted 2018-05-01
Plain-language summary
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity. Comparison of the peptide spectrum will be done for the pregnant and not pregnant patients.
Who can participate
Age range36 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria - Arm A - stimulated cycle:
* female aged less than 37 years (maximally 36y + 364d)
* no smoker
* normal menstrual cycles lasting between 25 to 35 days
* had been infertile for less than five years
* normal responder
* fewer than three failed cycles of assisted reproduction treatment, including fresh IVF/ intracytoplasmic sperm injection (ICSI) embryo transfer cycles and/or frozen-thawed embryo transfer cycles
* sperm obtained through ejaculation
* spermiogram more than 5 million sperm/mL
* BMI 19-29 kg/m2
* follicle stimulating hormone (FSH) \< 10 IU/L on the third day
* basal antral follicle count of 5-15
* undergoing the same routine gonadotrophin-releasing hormone agonist (GnRHa) long depot or gonadotrophin-releasing hormone antagonist (GnRH-ant.) protocol
* informed consent
Exclusion Criteria - Arm A - stimulated cycle:
* genetic disease
* metabolic and/or endocrine disorders
* polycystic ovary syndrome (defined by the Rotterdam criteria)
* women with prior diagnosis of endometriosis or adenomyosis
* previous gynecological/pelvic surgery except for salpingectomy
* repeated spontaneous abortions (two or more)
* previously less than 5 oocytes and/or serum anti-Mullerian hormone value \< 1.0 mIU/ml or more than 20 oocytes, milli-International unit (mIU)
* previous ovarian hyperstimulation syndrome (OHSS)
* presence of any structural abnormality of the reproductive system
* donor oocyte cycles
* severe male factor infertility \< 5 million sperm/mL
* low…
What they're measuring
1
Mass spectrometer analysis of the proteins from cervical mucus
Timeframe: 48 months
Trial details
NCT IDNCT04619524
SponsorThe Institute of Molecular and Translational Medicine, Czech Republic