Prenatal Behavioral Intervention to Prevent Maternal Cytomegalovirus (CMV) in Pregnancy

Inclusion Criteria: * enrollment in prenatal care before 20 weeks gestation * absence of CMV IgG on serological testing indicating CMV seronegative status or CMV positive (nonprimary) defined as maternal CMV infection pre-dating pregnancy defined by a high IgG avidity index or a positive CMV IgG in the presence of a negative CMV immunoglobulin M (IgM) Exclusion Criteria: * known major fetal anomalies or demise * planned termination of pregnancy * planned use of immune globulin, ganciclovir, or valganciclovir * maternal immune impairment (e.g., HIV infection, organ transplant on anti-rejection medications) * pre-enrollment ultrasound suggestive of established fetal CMV infection or positive fetal CMV results from culture or PCR * pre-enrollment CMV seroconversion or primary CMV infection in pregnancy * unable to determine if CMV infection is a nonprimary infection due to intermediate or undefined CMV serological test results * pre-enrollment blood, ultrasound, or amniotic fluid testing indicating congenital infection with rubella, syphilis, varicella, parvovirus, toxoplasmosis or other congenital infection * intention of the patient or of the managing obstetricians for the delivery to be outside of the University of Alabama at Birmingham hospital