Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor

Inclusion Criteria: * adults aged 18 years or greater * participants actively listed for heart, lung and/or kidney transplant * participants have already consented to receive HCV-viremic organs as part of the institution's clinical practice protocol (involves education and informed consent), and are able to sign informed consent for this research study. Exclusion Criteria: * participants who have a prior history of HCV infection regardless of treatment status, pre-existing human immunodeficiency virus (HIV) or hepatitis B virus (HBV) infection * participants who are not able to sign informed consent for this research study * participants who have not agreed to accept HCV+ organs as part of the UCSD clinical practice protocol * participants who are listed for a liver transplant (either as a single organ or combined organ transplant).