The study will test the feasibility of using Low Intensity Focused Ultrasound Pulsation (LIFUP) to treat motor symptoms in Parkinson's Disease (PD). LIFUP is a new technique that can increase brain activity in highly specific target areas and is MRI compatible. Thus, in real-time, it is possible to directly observe how LIFUP changes the brain areas important in PD by measuring its effects on brain activity, blood flow, and brain connectivity. If successful, this research will mark the first step towards a novel, non-invasive, non-medication treatment for PD.
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Motor Assessment 1: Unified Parkinson Disease Rating Scale (UPDRS) Section 3
Timeframe: Pre-LIFUP and Post-LIFUP at Day 1 and Day 15
Motor Assessment 2: Finger Tapping (Score)
Timeframe: Pre-LIFUP and Post-LIFUP at Day 1 and Day 15
Motor Assessment 2: Finger Tapping (Speed)
Timeframe: Pre-LIFUP and Post-LIFUP at Day 1 and Day 15
Motor Assessment 2: 9-Hole Pegboard Dexterity Test
Timeframe: Pre-LIFUP and Post-LIFUP at Day 1 and Day 15