Impact of a Monoamine Oxidase Inhibitor on the Phenotype of Blood Mononucleated Cells in Patients… (NCT04590222) | Clinical Trial Compass
CompletedNot Applicable
Impact of a Monoamine Oxidase Inhibitor on the Phenotype of Blood Mononucleated Cells in Patients With COVID-19
France51 participantsStarted 2020-11-20
Plain-language summary
The principal objective is to determine the impact of phenelzine on the activation phenotype of T cells and myeloid cells during SARS-CoV2 infection
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 1\. Individuals male or female ≥18 years of age at time of enrolment
* 2.Subject (or legally authorized representative provides non opposition form prior to initiation of any study procedure.
* 3\. Understands and agrees to comply with planned study procedure. (Agrees to the collection of venous blood per protocol).
* 4\. Has laboratory-confirmed SARS-CoV-2 infection as determined by PCR, or other commercial or public health assay in any specimen\<72hours prior to enrollment and/or a chest CT scan reported as highly likely SARS-CoV2 infection.
The different scales for severity are as follows:
* 5\. Non severe patients: Clinical assessment (evidence of rales/crackles on exam) or CT scan involvement AND SpO2\> 94% on room air, or ≤ 94% on room air but \> 94% with nasal Oxygen with a flow rate \<= 3l O2/min
For the severe infection's patients' group:
* 6\. Patients requiring mechanical ventilation and/or supplemental oxygen \>= 6l O2/min
For the obese patients 'group:
* 7\. Obese patients will be defined as an BMI \> 30
* 8\. Co inclusion in non-interventional researches is possible
Exclusion Criteria:
* Pregnant and breast-feeding women
* Patients previously treated by phenelzine (Nardil®)
* Persons unable to give their no opposition
* Persons under guardianship or curatorship
* No affiliated to social insurance.
* Inclusion in interventional researches
What they're measuring
1
levels of lymphocytes T DR + CD38 + and of monocytes CD14 dim + CD16 +.
Timeframe: through study completion, an average of 1 year