Assessing the Symptomatic Benefit of Acoustic Slow Wave Enhancement in Parkinson Disease

Inclusion Criteria: * Informed consent as documented by signature * Diagnosis of PD along international criteria with mild to moderate disease severity (Hoehn- Yahr (HY) stages ll-lll), * Self-reported sleep problems and subjectively impaired sleep quality (PDSS-2 sleep quality subscale (items 1-3 and 14) ≥7) * Stable home situation (e.g. long-term place to live) that allows for reliable application of intervention for the duration of the study * Ability to apply the intervention for the duration of study, either alone or with help of co-habitant * Sufficient German language comprehension to follow the study procedures and answer all questions related to the study outcomes * Dosing of dopaminergic and other PD treatment must have been stable for at least 14 days prior to the first intervention period * Negative pregnancy test during screening (except in women who are surgically sterilized/hysterectomized or post-menopausal for longer than 1 year), * Age above 18 years Exclusion Criteria: * Known presence of neurologic (other than PD), psychiatric, or sleep disorders (others than associated with PD) * Parkinsonism without response to levodopa; Atypical Parkinsonian syndromes * Severe medical conditions as renal insufficiency, liver failure or congestive heart failure * The regular use of benzodiazepines and other central nervous system (CNS)-depressant substances, as well as melatonin and other sleep inducing substances * Inability to hear the tones produced by the MHSL-Sle…