Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers

Exclusion criteria

• ✕. Have a fertility plan within 3 months after screening to the last medication, or refuse to use medically approved contraceptive methods;
• ✕. Drug abusers or drug urine screening positive;
• ✕. Smokers (average daily smoking 5 or more) or urine Nicotin positive.
• ✕. The average daily alcohol intake during the first month was more than 25 g (for example, 750 mL beer, 250 mL wine or 50 mL low spirits);
• ✕. Anyone who had eaten grapefruit or fruit juice products within 2 days before administration, any food or drink containing caffeine (such as coffee, tea, chocolate, cola or other caffeinated carbonated drinks, etc.) and foods or drinks rich in purine food or alcohol.
• ✕. The researchers judged that the subjects had medical conditions that affected the absorption, distribution, metabolism and excretion of drugs or reduced compliance.
• ✕. Those with sUA \> 420 µmol / L during the screening period, or those with a previous history of hyperuricemia and / or gout;
• ✕. Those with estimated glomerular filtration rate (eGFR) \< 90 during the screening period;