Evaluation of the Nasal and Conjunctival Response in Subjects Allergic to Birch Pollen in the ALYATEC Environmental Exposure Chamber

Inclusion Criteria: * A clinical history of allergic rhinitis to birch pollen for at least 2 consecutive pollen seasons requiring the taking of a symptomatic drug with or without associated asthma * Positive skin prick tests for birch pollen (\> 3 mm) * IgE specific to birch \> 0.75 kUI / L. * Positive unit rapid nasal provocation test for birch pollen * Subjects having signed informed consent * Subjects affiliated to a social security scheme * Subjects able to understand and complete the procedures related to the study * Women of childbearing potential should have a negative pregnancy test throughout the study period with effective contraception Exclusion Criteria: * Specific immunotherapy (SIT) for birch allergens for more than a month in the 3 years preceding the screening * Current use of Specific immunotherapy for another allergen * Medical history of anaphylaxis following exposure to birch pollen * Medical history of anaphylaxis linked to another allergen in the last 6 weeks * Nasal polyps, nasal septum deviation or diagnosis of non-allergic rhinitis * Subjects allergic to indoor environmental allergens (cat allergens, mold, dust mites) with - Obvious exposure to these allergens. * Uncontrolled allergic pathology (rhinitis, conjunctivitis) * Forced expiratory volume in 1 second (FEV1) \<70% of predicted normal values * Moderate to severe asthma (GINA 3 to 5)