Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation (NCT04583046) | Clinical Trial Compass
CompletedNot Applicable
Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
South Korea78 participantsStarted 2020-11-02
Plain-language summary
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.
Who can participate
Age range
40 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. scheduled for VATS lobectomy
. 40 \< age \< 80
. American Society of Anaesthesiologists(ASA) physical status classification I\~III
. BMI \> 30 kg /m2
Exclusion criteria
. American Society of Anaesthesiologists(ASA) physical status classification IV or more
. NYHA class III\~IV
. Severe obstructive lung disease and/or restrictive lung disease patients
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
Timeframe: 20 minutes after iloprost inhalation (T2)
2
Result of arterial blood gas analysis : partial pressure of oxygen in the arterial blood(PaO2)/Fraction of inspired oxygen(FiO2) ratio (P/F ratio)
Timeframe: 20 minutes after iloprost inhalation (T2)
3
Result of arterial blood gas analysis : Oxygen saturation in arterial blood(SaO2)
Timeframe: 20 minutes after iloprost inhalation (T2)