Correlation Between Clonal Hematopoiesis, Cardio-vascular Events, Inflammation and Atherosclerosis (NCT04581057) | Clinical Trial Compass
CompletedNot Applicable
Correlation Between Clonal Hematopoiesis, Cardio-vascular Events, Inflammation and Atherosclerosis
France114 participantsStarted 2020-06-23
Plain-language summary
This study aims at evaluating the prevalence of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in patients over 75 presenting with a first cardio-vascular event (CVE). The investigators will also determine if CHIPs are more frequent in this population compared to a control cohort without CVE. An association between CHIP, a systemic inflammation and increased atherosclerosis will also be assessed.
Who can participate
Age range75 Years
SexALL
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Inclusion Criteria:
* Patients (male or female) over 75 years old
* Patients with a first CVE (myocardial infarction) of atheromatous origin that occurred between 2 and 7 months before inclusion
* Absence of evidence of hematological malignancy (known or obvious by the results of blood counts)
* Subject registered with a social security scheme
* Written informed consent obtained
Exclusion Criteria:
* Patients who did not presented any CVE in the last 7 months
* Patients with CVE with a non-atheromatous origin (dissection, embolic, …)
* Presence of an unbalanced diabetes (defined as HbA1C \> 10%)
* History of previous CVE before 75 year-old : myocardial infarction, stroke of atheromatous origin
* Hematological malignancy (known or obvious on the results of blood counts)
* Chronic inflammatory disease (cancer, vasculitis, rheumatism, hepato-gastro-intestinal diseases).
* Long term anti-inflammatory treatments:
* Corticoids
* Nonsteroidal anti-inflammatory drugs
* Aspirin (\> 325 mg per day)
* Cyclo-oxygenase II inhibitors
* Persons under judicial safeguards, trustee or curators
* Person deprived of judicial or administrative freedom
* Person unable to give her consent
* Non-cooperative person
* Exclusion period after another clinical study or participation to another interventional clinical study testing a drug in the 30 days before inclusion