The Impact of Exercise-Induced Cardiac Remodeling on Myocardial Efficiency (NCT04580693) | Clinical Trial Compass
CompletedNot Applicable
The Impact of Exercise-Induced Cardiac Remodeling on Myocardial Efficiency
United States87 participantsStarted 2019-02-28
Plain-language summary
This research study is being conducted to find out how heart function and energy use differ among healthy endurance athletes, individuals who do not exercise regularly, and patients with hypertrophic cardiomyopathy. The research study involves taking part in a cardiopulmonary exercise test (CPET), two positron emission tomography (PET) scans, an echocardiogram, and blood draws. The study will consist of a total of three visits scheduled over a maximum of two weeks. By determining how heart function and energy use differ between our three groups of healthy endurance athletes, individuals who do not exercise regularly, and patients with hypertrophic cardiomyopathy, the investigators hope to have this work translate into a novel clinical tool for differentiating pathologic changes of the heart from physiological changes in heart. This is otherwise known as "gray-zone" left ventricular hypertrophy, or enlargement of the left ventricle.
Who can participate
Age range18 Years – 60 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Endurance Athletes:
* Age ≥ 18-60
* Official participation in a collegiate varsity rowing team OR participation in competitive endurance athletics (defined as \>= 10 hours of exercise training per week with the majority dedicated to endurance activities (i.e. cycling, rowing, running).
Inclusion Criteria for Healthy Volunteers:
* Age ≥ 18-60
* 0-5 hours of exercise per week without anticipated changes in exercise habits over study period
* Able to exercise on an upright bicycle ergometer
Exclusion Criteria for Endurance Athletes and Healthy Volunteers:
* Known medical disease (including but not limited to known cardiac or pulmonary disease, diabetes or contraindications to exercise testing such as uncontrolled cardiac arrhythmia, excessive blood pressure of more than 200/100 mmHg at rest, active exacerbation of congestive heart failure or reactive airways disease).
* Pregnancy
Inclusion Criteria for HCM Patients:
* Established HCM diagnosis as per above (20 subjects)
* Age ≥ 18-50
* No anticipated changes to baseline exercise program (if any) over the study period
* Able to exercise on an upright bicycle ergometer
Exclusion Criteria for HCM Patients:
* Obstructive LVOT gradient \> 30 mmHg, at rest or with provocation.
* Reduced LVEF \< 53%.
* NYHA class III or IV heart failure symptoms.
* History of sudden cardiac death or hemodynamically significant ventricular tachycardia.
* History of unexplained syncope.
* Having a Class I or IIa AHA/ACC in…