The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart disease (RHD) valvular pathology progression. This feasibility study is intended to confirm the number of readily recruitable subjects, assess recruitment rate, and assess the rate of valve pathology via echocardiograms. These results are necessary and sufficient to facilitate the successful design of a large full scale randomized trial to determine whether statins improve outcomes in RHD. Successful treatment of RHD would fundamentally shift the RHD management paradigm world-wide, improve the lives of millions afflicted with RHD, and subsequently, decrease health care spending on RHD management.
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Enrollment rate
Timeframe: Measured at study enrollment
Medication adherence
Timeframe: Measured at month 1
Medication adherence
Timeframe: Measured at months 6
Medication adherence
Timeframe: Measured at months 12
Medication adherence
Timeframe: Measured at months 18
Retention rate
Timeframe: Measured at Month 18
Rate of progression of valvular disease
Timeframe: Change between baseline and Month 18