The present study aims to investigate a potential mechanism of successful CBT for panic disorder, i.e., the reduction of excessive anxious apprehension and fear responses to panic-related body symptoms in the context of CBT treatment. In the present non-randomized interventional study, effects of cognitive behavior therapy on reported symptoms and fear responses to panic-related body symptoms are investigated. It is expected that symptom improvement during CBT is associated with a decrease in the activation of the brain's fear network to panic-related body symptoms.
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Change in defensive activation to interoceptive threat
Timeframe: change from pre-intervention/pre-waiting period (baseline) to immediately after CBT or waiting period
Change in panic symptomatology and severity (PAS)
Timeframe: change from pre-intervention/pre-waiting period (baseline) to immediately after CBT or waiting period
Change in the severity of anxiety symptomatology (HAM-A=
Timeframe: change from pre-intervention/pre-waiting period (baseline) to immediately after CBT or waiting period
Change in anxiety sensitivity (ASI)
Timeframe: change from pre-intervention/pre-waiting period (baseline) to immediately after CBT or waiting period