Bilateral Knee Osteoarthritis: Intra-articular Injection of Filtered Autologous Adipose Tissue Versus Placebo
Italy100 participantsStarted 2021-02-22
Plain-language summary
The purpose of the study is to assess the radiological and clinical outcomes comparing two different treatments (Filtered Autologous Adipose Tissue versus Placebo) in patients affecting bilateral knee osteoarthritis.
After be randomized, every patient will be treated in both legs, one leg with Adipose Tissue and the other one with Placebo.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. bilateral degenerative chondropathy of the knees showing at least a grade 2-3 kellgren-lawrence classification (absence of severe osteoarthritis)
✓. An overall Pain subscale score of the Western Ontario and McMaster Universities Osteoarthritis Index between a value of 9 and 19.
✓. Failure, intended as the persistence of symptomatology, after at least one conservative treatment cycle (pharmacological, physiotherapeutic or infiltrative treatment);
✓. Ability and informed consent of patients to actively participate in the rehabilitation protocol and clinical and radiological follow-up;
Exclusion criteria
✕. Patients incapable of understanding and wanting;
✕. Diagnosis of leukaemia, known presence of metastatic malignant cells, ongoing or planned chemotherapy;
✕. Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis or arthritis resulting from another inflammatory disease; infection with human immunodeficiency virus (HIV), viral hepatitis; chondrocalcinosis;
✕. Patients with uncontrolled diabetes mellitus;
✕. Patients with uncontrolled thyroid metabolic disorders;
✕. Patients who abuse alcoholic beverages, drugs or medicines;
✕. Patients with misalignment of the lower limbs above 10 degrees;
What they're measuring
1
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)