This is a first in-human study to investigate the safety, tolerability and efficacy of zifibancimig administered through intravitreal (IVT) injections and via the port delivery (PD) implant in participants with neovascular age-related macular degeneration (nAMD).
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Percentage of Participants With Ocular and Systemic (Non-ocular) Adverse Events (AEs)
Timeframe: Part 1: Baseline up to Week 24; Parts 2 & 3: Baseline up to Week 48
Percentage of Participants With Ocular AEs During the Post-operative and Follow-up Periods
Timeframe: Parts 2 and 3: From Day 1 to Week 4 and during follow-up period (up to Week 48)
Percentage of Participants With Adverse Events of Special Interest (AESIs) Including Ocular AESIs
Timeframe: Part 1: Baseline up to Week 24; Parts 2 and 3: Baseline up to Week 48
Percentage of Participants With Ocular AESIs During the Post-operative and Follow-up Periods
Timeframe: Parts 2 and 3: From Day 1 to Week 4 and during follow-up period (up to Week 48)
Duration of Ocular AESIs
Timeframe: Part 1: Baseline up to Week 24; Parts 2 and 3: Baseline up to Week 48
Duration of Ocular AESIs During the Post-operative and Follow-up Periods
Timeframe: Parts 2 and 3: From Day 1 to Week 4 and during follow-up period (up to Week 48)
Percentage of Participants With Adverse Device Effects (ADEs)
Timeframe: Parts 2 and 3: Baseline up to Week 48
Duration of ADEs
Timeframe: Parts 2 and 3: Baseline up to Week 48
Percentage of Participants With Anticipated Serious ADEs (ASADEs)
Timeframe: Parts 2 and 3: Baseline up to Week 48
Duration of ASADEs
Timeframe: Parts 2 and 3: Baseline up to Week 48
Change From Baseline in Early Treatment Diabetic Retinopathy Study - Best Corrected Visual Acuity (ETDRS-BCVA) Score at Week 48
Timeframe: Part 3: Baseline (baseline visit, before implant insertion), and Week 48