Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies (NCT04566393) | Clinical Trial Compass
AVAILABLENot Applicable
Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
United States
Plain-language summary
The objective of this expanded access program is to provide ulixertinib (BVD-523) for compassionate use in advanced cancer patients with MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations who have incomplete response to or have exhausted available therapies.
Ulixertinib is available for treatment as monotherapy or in combination with other clinically tolerable agent(s), conditionally approved by the drug manufacturer.
Who can participate
Age range12 Years
SexALL
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Inclusion criteria
✓. In the opinion of the treating physician, the patient has exhausted or has inadequate response to available anti-cancer treatments.
✓. In the opinion of the treating physician, the patient has adequate organ function to tolerate ulixertinib as defined in section 6.1
✓. Male or female patients aged ≥ 12 years.
✓. Patient must be able to swallow and retain orally administered medication.
✓. For females, evidence of post-menopausal status or negative urinary or serum pregnancy test for pre-menopausal patients.
✓. Highly effective contraception for both male and female patients throughout the treatment and for at least 4 months after last treatment administration. In patients under the age of 18, who are not sexually active, abstinence is an acceptable form.
✓. Toxicities related to any prior treatments are either stable, stable on supportive therapy, resolved, or in the opinion of the treating physician, clinically non-significant
✓. Ability to understand a written informed consent document, and the willingness to sign it. Assent will be obtained when appropriate based on the patient's age.
Exclusion criteria
✕. Patient is already participating in or qualifies for and is able to enroll in a clinical trial of ulixertinib (BVD-523).
✕. Patient has received systemic therapy with an investigational agent within 5 half-lives or 14 days prior to starting ulixertinib treatment, whichever is shorter.
✕. Patient has received radiotherapy within 14 days prior to the first dose of ulixertinib treatment other than for the allowable treatment of symptomatic bone metastasis.
✕. A history of current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR)
✕. Current evidence of uncontrolled, significant intercurrent illness that would, in the treating physician's judgment, contraindicate the patient's treatment with ulixertinib due to safety concerns.
✕. Patients who, in the opinion of the treating physician, have not fully recovered from recent major surgery to a sufficient extent to tolerate treatment with ulixertinib.
✕. Known hypersensitivity to ulixertinib or any component in its formulation.
✕. Patients taking prohibited medications as described in current Investigator's Brochure.