By InvitationNot Applicable

Transforming Research and Clinical Knowledge in Spinal Cord Injury

United States726 participantsStarted 2015-05-14

Plain-language summary

The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics of acute traumatic spinal cord injury (SCI). TRACK-SCI seeks to combine high quality care variables with high density physiology data collection to better understand diagnose, characterize, and track the temporal profile of recovery for SCI patients. The Investigators are enrolling patients within 24 hours of injury who present to a TRACK-SCI site with a spinal cord injury that meets eligibility criteria.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * For SCI group: individuals at least 18 years of age recently diagnosed with acute, traumatic spinal cord injury * For Trauma Control group: individuals at least 18 years of age recently diagnosed with acute, traumatic injury that is not spinal cord injury * For Healthy Control group: generally healthy individuals at least 18 years of age not recently diagnosed with acute, traumatic injury (including SCI) Exclusion Criteria: * Individuals who are pregnant * Individuals who are in-custody/prisoners * Individuals who are under psychiatric hold * For non-SCI individuals, they must not have had a spinal cord injury in the past * For non-SCI individuals, they must not have a history of previous central nervous system injury (i.e. stroke, spinal cord injury, traumatic brain injury, seizures, etc.)

What they're measuring

Gene expression level in number of messenger RiboNucleic Acid (mRNA) transcripts for all genes expressed in white blood cells

Timeframe: Baseline (healthy control group), or as close as possible to time of injury (SCI and trauma control group)

International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) (SCI Only)

Timeframe: From admission to 12 months post-injury

Trial details

NCT IDNCT04565366

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-12-01

View on ClinicalTrials.gov More Spinal Cord Injuries trials