Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure (NCT04549701) | Clinical Trial Compass
CompletedNot Applicable
Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure
Argentina60 participantsStarted 2022-03-20
Plain-language summary
Between 25% and 30% of patients hospitalized for acute heart failure (AHF) are readmitted within 90 days after discharge. Mostly due to persistent congestion on discharge. However, as the optimal evaluation of decongestion is not clearly defined, it is necessary to implement new tools to identify subclinical congestion to guide treatment.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
\- Hospitalization of 24 hours or greater for decompensated heart failure defined as new-onset of symptoms or worsening of previous symptoms (including orthopnea, progression to FC III-IV, bendopnea or fatigue) or signs of volume overload.
and - Jugular venous distension, hepatojugular reflux, lower extremity edema or signs of pulmonary congestion.
and
* Chest X-ray with signs suggestive of pulmonary congestion. and
* Elevated Ā“pro-B-type natriuretic peptide (NT-proBNP) levels of 450 pg/mL, 900 pg/mL, and 1800 pg/mL for ages \< 50 years, 50 to 75 years, and \> 75 years, respectively, within 24 hours of admission (53,54).
and
\- Sufficient ultrasound visualization to assess IVC and lungs.
Exclusion Criteria:
* Not willing to participate.
* Life expectancy of less than 6 months.
* Uninterpretable lung or inferior vena cava ultrasound.
* Transfer to another hospital before hospital discharge.
* SBP \< 90 mm Hg.
* Chronic kidney disease (creatinine clearance \<30 mL/min calculated with the MDRD equation or hemodialysis).
* Requirement for invasive or noninvasive ventilator support.
* Pregnancy.
* Low cardiac output syndrome/cardiogenic shock.
* Death during index hospitalization.
* Acute coronary syndrome, myocardial revascularization or heart valve replacement within the previous 3 months.
* Being on heart transplant waiting list.
* Cardiac resynchronization therapy device implanted within the previous 3 months.
* Severe tricuspid valve regurgitation.ā¦