Objective: This 3-year multisite RCT will determine the effectiveness of a targeted multidomain intervention (T-MD) (anxiety/mood, cognitive, migraine, ocular, vestibular; and sleep, autonomic) compared to usual care (behavioral management) in military-aged civilians with complex mTBI.
Who can participate
Age range18 Years – 49 Years
SexALL
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Inclusion Criteria: Participants must meet ALL of the following inclusion criteria:
* 18-49 years of age
* Normal/corrected vision
* Diagnosed with complex mTBI in the past 8 days-6 months with clear mechanism of injury
* Glascow coma scale (GCS) score no less than 13
* Reported or sign of mTBI including loss of consciousness, amnesia, disorientation/confusion, dizziness, imbalance, memory problems, vomiting
* Complex mTBI-related symptoms and/or impairments in at least one of the following areas: anxiety/mood, cognitive, migraine, ocular, vestibular, sleep, autonomic; per a comprehensive assessment, clinical exam/interview, and adjudication process.
Exclusion Criteria: Participants will be excluded if they meet one or more of the following exclusion criteria:
* History of vestibular disorder (e.g., benign paroxysmal positional vertigo, unilateral, or bilateral vestibular hypofunction)
* History of neurological disorder
* Previous moderate to severe TBI
* History of brain surgery, malformations or tumors
* Diagnosed with cardiac, peripheral or cerebrovascular disease
* Experienced chest pain or shortness of breath while at rest or with mild exertion
* Been told by a doctor to only conduct physical activity under medical supervision
* Previous moderate to severe TBI
* \< 8 days or \>6 months following current complex mTBI
* Currently pregnant or become pregnant during study
* Currently involved in litigation associated with current or previous mTBI
* Currently on workman's …
What they're measuring
1
Neurobehavioral Symptom Inventory (NSI)
Timeframe: NSI will be measured from baseline to 3 months.
2
Patient Global Impression of Change (PGIC)
Timeframe: The PGIC will be measured from baseline to 3 months.
3
Functional Near-infrared Spectroscopy (fNIRS)
Timeframe: fNIRS will be conducted two times, once baseline and again at the 4 week visit.