To assess the impact of rapid diagnostic testing of patients with Acute Respiratory Tract Infection (ARTI) at the emergency department, on (1) hospital admission rates and (2) antimicrobial prescriptions (days of treatment) and (3) the non-inferiority in terms of clinical outcome. Geographical and seasonal variation will be assessed on a real time basis including pathogens of public health interest. The impact will be stratified within age groups and risk factors in order to determine the long-term clinical, public health and economic determinants for the integration of diagnostics in a global and sustainable perspective.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Adults (≥18 years old) presenting to the Emergency Room with an acute illness (present for 14 days or less) with cough, and with at least 1 other lower respiratory tract symptom or clinical sign at physical examination:
✓. to treat patient with antibiotics and/or to hospitalize patient
✓. that the rapid syndromic diagnostic test result can be awaited up to a maximum of 4 hours before the decision to discharge the patient or to initiate antibiotic therapy.
Exclusion criteria
✕. Development of ARTI more than 48 hours after hospital admission (hospital acquired);
✕. Patients with cystic fibrosis;
✕. Less than 14 days since the last episode of respiratory tract infection;
✕. Pregnancy (confirmed by pregnancy test) and breastfeeding;
✕. Any clinically significant abnormality identified at the time of screening that in the judgment of the Investigator would preclude safe completion of the study or constrain endpoints assessment such as major systemic diseases or patients with short life expectancy;
What they're measuring
1
Days Alive Out of Hospital (Superiority Endpoint)
Timeframe: Day 1 - Day 14
2
Days on Therapy (DOT) With Antibiotics (Superiority Endpoint)