To assess changes in pain and function in patients with discogenic low back pain after a standard of care intradiscal injection of Platelet-Rich Plasma (PRP).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age greater than 18 years of age at day of enrollment.
✓. Clinical diagnosis of refractory discogenic low back pain for \>3 months.
✓. Magnetic resonance imaging pathology consistent with clinical symptoms/signs or positive lumbar provocative discography according to SIS/IASP standards at one or two levels.
✓. Back pain greater than leg pain with an intensity of at least 4/10 or higher using the Numerical Rating Scale (NRS).
✓. Pain duration of more than 12 weeks despite trial of conservative therapy (medications, physical therapy, or chiropractic care) for 2 months.
Exclusion criteria
✕. Refusal to participate, provide consent, or provide follow-up information for the 24-month duration of the study.
✕. Contraindications to intradiscal injection of PRP (active infection, bleeding disorders, current anticoagulant or antiplatelet medication use, allergy to iodinated contrast, penicillin or clindamycin and pregnancy or breastfeeding).
✕. More than 2 levels of clinical or discogram proven pain.
✕. Non-discogenic source of low back pain as identified by separate diagnostic blocks.
✕. Negative lumbar provocation discography.
✕. Active moderate to severe lumbar radiculopathy.
✕
What they're measuring
1
Numeric Rating Scale for Low Back Pain at 2-Month Follow-up