Objective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS). Methodologies: Patients with DS were randomly assigned to the groups: aPDT (n=30) and nystatin (NYS, n=35). aPDT patients received 6 aPDT sessions, three times a week for 15 days, which involved PDZ (200 mg/L) topical application (20 min) on the palate and upper denture, followed by light emitting diode (LED) illumination (660 nm, 50 J/cm²). NYS patients were instructed to rinse one dropper of this medication for one minute, four times a day, for 15 days. Microbiological collections of dentures and palates were performed and cultured on blood agar and CHROMAgar Candida. Microbial viability was determined, and photographs of the palates were taken for clinical evaluation. Data were analyzed by Repeated Measure Linear Model and Bonferroni (p≤0.05).
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Microbial Viability at baseline
Timeframe: The recovery of microorganisms was performed before the tretaments (at the baseline - initial).
Microbial Viability at the end of the treatments
Timeframe: The recovery of microorganisms was performed immediately at the end of the treatments.
Microbial Viability on day 15
Timeframe: The recovery of microorganisms was performed on day 15 after the end of the treatments.
Microbial Viability on day 30
Timeframe: The recovery of microorganisms was performed on day 30 after the end of the treatments.
Microbial Viability on day 45
Timeframe: The recovery of microorganisms was performed on day 45 after the end of the treatments.