Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogen… (NCT04531631) | Clinical Trial Compass
CompletedPhase 2
Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogenic Diabetes
Hong Kong18 participantsStarted 2020-09-30
Plain-language summary
Diabetes is a disorder of energy energy metabolism. Glucose is the main energy substrate for generation of ATP to maintain cellular metabolism, structure and function. Glucokinase (GK) serves as a glucose sensor for the initiation of the energy generation.for energy metabolism. Dorzagliatin is a novel, first-in-class, dual-acting allosteric GK activator (GKA). It increases the affinity of GK for glucose by directly binding a pocket distal to its active site, thus lowering the set point for glucose-stimulated insulin secretion in the beta-cell.
Dorzagliatin is a new drug which acts as GK sensor activator (GKA). It can restore the sensitivity of the pancreas cells to glucose and improve glucose control. The drug has been trialled in healthy volunteers and in individuals with type 2 diabetes.
The aim of this study is to understand the way in which dorzagliatin works to improve blood sugar control in people with diabetes. The study will look at how dorzagliatin affects insulin secretion and the sensitivity of the pancreas to changes in blood sugar levels. We will examine whether dorzagliatin can restore the function of this GK sensor in patients with known mutations. In a cross-over study, we will evaluate the effects of dorzagliatin, a specific GKA versus placebo in terms of insulin secretion and beta-cell glucose sensitivity in patients with newly-diagnosed T2D and patients who are known heterozygous carriers of GK mutations.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Individuals aged ≥ 18 years but \< 65years
✓. Male or female
✓. Body mass index of over 18 kg/m2 and \< 30 kg/m2 Additional Inclusion criteria for recent-onset T2D group
Exclusion criteria
✕. Subjects who do not agree to participate in this study.
✕. Country of birth is unknown
✕. Body weight less than 45kg
✕. Acute phase of cerebrovascular and cardiovascular diseases (within 6 months of recruitment).
✕. Subjects with severe renal dysfunction as defined by eGFR \<30 ml/min/1.73m2 or patients receiving renal dialysis (such as haemodialysis or continuous ambulatory peritoneal dialysis).
✕. Severe hepatic dysfunction as defined by AST and/or ALT \> 3 times upper limit of normal
✕. Severe cardiovascular disease, history of stroke, heart failure (NYHA III or IV) or history of myocardial infarction within last 12 months