Eltrombopag Combining Rituximab Versus Eltrombopag in the Management of Primary Immune Thrombocyt… (NCT04518475) | Clinical Trial Compass
RecruitingPhase 4
Eltrombopag Combining Rituximab Versus Eltrombopag in the Management of Primary Immune Thrombocytopenia (ITP) in Adults
China224 participantsStarted 2020-08-10
Plain-language summary
This multicenter randomized, open-label study aimed to compare the efficacy and safety of eltrombopag combining rituximab with eltrombopag in China adult ITP patients .This study was be conducted in adult ITP patients who had not responded to or had relapsed after previous treatment of ITP, including first line therapy and /or splenectomy.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion criteria
✓. Signed written informed consent
✓. Age from 18 to 60 years old
✓. Diagnosed with ITP and have a platelet count of \<30 ×10\^9/L on Day 1 (or within 48 hours prior to dosing on Day 1).
✓. Patients who have no response or relapsed after splenectomy(at least more than 6 months). Or patients who have not been splenectomised and have either not responded to one or more prior therapies, or who have relapsed prior therapy.
✓. Subjects treated with previous therapy(including but not limited to corticosteroid, azathioprine, danazol, cyclosporin A, mycophenolate mofetil) must have been completed prior to randomization, or must not be increasing a dose after enrollment.
✓. No pre-existing cardiac disease within the last 3 months. No arrhythmia known to increase the risk of thrombolic events (e.g. atrial fibrillation), or patients with a Corrected QT interval (QTc) \>450msec or QTc \>480 for patients with a Bundle Branch Block.
✓. No pre-existing infection within the last 1 months(including but not limited to pulmonary infection)
✓. Laboratory tests for coagulation function showed that prothrombin time (PT/INR) and activated partial thromboplastin time (APTT) no exceed normal by more than 20%. No history of clotting disorder, other than ITP.
Exclusion criteria
✕. Patients with any prior history of arterial or venous thrombosis, and with following risk factors: cancer, Factor V Leiden, ATIII deficiency, antiphospholipid syndrome.
What they're measuring
1
Treatment response
Timeframe: From the start of study treatment (Day 1) up to the end of week 12.
Trial details
NCT IDNCT04518475
SponsorInstitute of Hematology & Blood Diseases Hospital, China
✕. Subjects is currently receiving treatment with another study medication.
✕. Any laboratory or clinical evidence for HIV infection.
✕. Any clinical history for hepatitis C infection; chronic hepatitis B infection; or any evidence for active hepatitis at the time of subject screening. Laboratory test shows positive serology for Hepatitis C or Hepatitis B (HB). In addition, if negative for HBsAg but HBcAb positive (regardless of HBsAb status), a HB DNA test will be performed and if positive the subject will be excluded.
✕. History of platelet aggregation that prevents reliable measurement of platelet counts.
✕. Any clinically relevant abnormality, other than ITP,which in the opinion of the investigator makes the subject unsuitable for participation in the study.