Longitudinal Neuroimaging in Sturge-Weber Syndrome (NCT04517565) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Longitudinal Neuroimaging in Sturge-Weber Syndrome
United States80 participantsStarted 2020-03-01
Plain-language summary
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.
Who can participate
Age range3 Months – 30 Years
SexALL
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Inclusion criteria
✓. Subjects with Sturge-Weber syndrome (SWS):
✓. Age 3 months - 30 years;
✓. Presence of a facial port-wine birthmark (PWB) indicating a risk for SWS and/or evidence of SWS brain involvement based on the presence of one or more intracranial SWS brain abnormalities from previous clinical imaging (MRI or computed tomography) scan(s) with or without a facial PWB. SWS brain abnormalities can include both brain vascular and/or parenchymal abnormalities (including atrophy, calcification, etc.);
✓. In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language.
✓. Healthy control subjects:
✓. Age 3 years - 30 years;
✓. No history of neurological or psychiatric disorder
Exclusion criteria
✕. Metal in the head or mouth that would preclude safe, artifact-free MRI scanning; or any other metal or electronic device contraindicated for MRI scanning.
What they're measuring
1
Accuracy of detection of Sturge-Weber syndrome brain involvement by a novel fast magnetic resonance imaging (MRI) approach as compared to standard MRI.
Timeframe: During procedure
2
Correlation of enlarged cerebral deep vein scores, measured by magnetic resonance imaging (MRI), with full scale IQ acquired within 1 day.
Timeframe: 1 day
3
Correlation of diffusion tensor imaging (DTI) brain connectivity score with verbal IQ acquired within 1 day.
Timeframe: 1 day
4
Correlation of diffusion tensor imaging (DTI) brain connectivity score with non-verbal IQ acquired within 1 day.