UnknownNot Applicable

The Effect of Blood Donation on Hematological and Iron Indices and Detection of Autologous Blood Transfusion

Denmark48 participantsStarted 2018-10-01

Plain-language summary

Blood donations is a essential and crucial in the clinic. Normal biological variation of relevant biomarkers and hormones before the donation of 450 mL whole blood as well as the expected alterations in systemic levels of plasma iron indices and RBC measures up to 4 weeks after donation in healthy, non-anemic, young men and women is investigated Likewise, the possibilities for detecting autologous blood transfusion is investigated.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion Criteria: * Relative maximum oxygen uptake (VO2-max) of at least 55 ml O2/min/kg for male participants and 50 ml O2/min/kg for female participants Exclusion Criteria: * Age * Insufficient fitness level * Blood donation 3 months prior to enrollment * Altitude exposure 2 months before enrollment * Hypertension

What they're measuring

Hemoglobin centration

Timeframe: 6 days after reinfusion

reticulocyte percentage

Timeframe: 6 days after reinfusion

OFF-score

Timeframe: 6 days after reinfusion

Homeostatic markers of iron metabolism

Timeframe: 6 days after reinfusion

Trial details

NCT IDNCT04514978

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-08-31

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