WithdrawnNot Applicable

Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Stopped: Lack of Funding

Turkey (Türkiye)0Started 2020-09-01

Plain-language summary

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ARDS defined by Berlin Criteria longer than 24 hours * Undergoing mechanical ventilation * Noradrenaline demand \>0.1 mcg/kg/min Exclusion Criteria: * Not meeting ARDS criteria * Noninvasive mechanical ventilation * ARDS resolved shorter than 24 hours * Shock resolved

What they're measuring

Extravascular Lung Water Index

Timeframe: 1 day

Pulmonary vascular permeability index

Timeframe: 1 day

Trial details

NCT IDNCT04508933

SponsorIstanbul University - Cerrahpasa

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-09-30

View on ClinicalTrials.gov More Respiratory Distress Syndrome, Adult trials