Combining Neuro-Imaging and Non-Invasive Brain Stimulation for Clinical Intervention in Opioid Use Disorder

Inclusion Criteria: * Current diagnosis of opioid use disorder * Enrolled in a methadone treatment program for at least 2 months in Hennepin Healthcare and be clinically stable. * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnostic criteria for opioid use disorder * Participants may have current comorbid drug use, but their primary substance use disorder diagnosis must to be based on opioid use. * Participants must have the intention to remain in the methadone treatment program until the end of the intervention portion of the study. Exclusion Criteria: * Any medical condition or treatment with neurological sequelae (i.e. stroke, tumor, loss of consciousness\>30 min, HIV) * Head injury resulting in a skull fracture or a loss of consciousness exceeding 30 minutes (i.e., moderate or severe TBI) * Any contraindications for tDCS or MRI scanning (tDCS contraindication: actively receiving treatment for seizures or epilepsy; MRI contraindications; metal implants, pacemakers or any other implanted electrical device, injury with metal, braces, dental implants, non-removable body piercings, pregnancy, breathing or moving disorder) * Current active psychosis or mania * Presence of a condition that would render study measures difficult or impossible to administer or interpret (e.g. current mania, active psychosis) * Primary current substance use disorder diagnosis on a substance other than opioid except for caffeine or nicotine * Current stimulant use diso…