MSC in Patients With Xerostomia Post XRT in Head and Neck Cancer

Inclusion Criteria: * Willing to provide informed consent * Willing to comply with all study procedures and be available for the duration of the study * Histological diagnosis of Head and Neck Cancer (HNC) and ≥ 2 years from completion of treatment for HNC, either clinically or radiologically No Evidence of Disease (NED), as assessed by ENT or Radiation Oncologist within 28 days of study registration * Individuals at least 18 years of age and no older than 90 years of age * Xerostomia defined as less than or equal to 80 percent of baseline (pre-radiation) salivary function per patient estimate * Karnofsky performance status ≥ 70, patient eligible for bone marrow aspirate with wakeful anesthesia * Radiographically confirmed bilateral submandibular glands * Females of childbearing potential must agree to have a negative urine or serum pregnancy test within 7 days prior to bone marrow biopsy. A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: * has not undergone a hysterectomy or bilateral oophorectomy; or * has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months) * Women of childbearing potential in sexual relationships with men must have used an acceptable method of contraception for 30 days prior to study registration and agree to use an acceptable …