Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM

Inclusion criteria

• ✓. Histologically confirmed glioblastoma multiforme (GBM) and are at first or second relapse.
• ✓. ≥ 18 years of age
• ✓. Have measurable disease of at least one solitary lesion with a dimension between 1 cm and 5 cm according to RANO
• ✓. Karnofsky performance status (KPS) ≥ 60
• ✓. Adequate organ function defined by laboratory values as follows: Creatinine \< 140 µmol/L (1.6 mg/dL); if borderline, the creatinine clearance ≥40 mL/min, Bilirubin \< 20% above the upper limit of normal, AST and ALT ≤ 2.5 the upper limit of normal.
• ✓. Absolute Neutrophil count baseline (ANC) ≥1500 cells/uL, Hemoglobin baseline ≥ 9.0 g/dL and Platelets baseline ≥ 100,000 cells/uL prior to the start of study treatment.
• ✓. Female of childbearing potential (FCBP) must not be pregnant and agree to not becoming pregnant for at least 42 days following the start of the treatment.
• ✓. Patients with HIV/AIDs are eligible if they have not had an opportunistic infection within the past 12 months

Exclusion criteria