Improved Adherence With Extended Venous Thromboembolism Prophylaxis After Major Cancer Surgery

Inclusion Criteria: * Patients of at least 18 years of age, discharged after hepato-biliary, colorectal or gynecology-oncology abdominal/pelvic surgery (laparoscopic or open) for cancer and considered at increased risk for VTE (e.g. previous history of VTE, residual cancer, slow mobilization, obesity, comorbidities). * Written informed consent obtained. Exclusion Criteria: * Patient unable to take tablets, even if crushed. * Active bleeding. * Venous thromboembolism diagnosed during the hospitalization. * Severe hepatic impairment (Child Pugh class C). * Severe renal failure on dialysis or with calculated creatinine clearance \<15 mL/min. * Platelet count \<50·109/L. * Concomitant treatment with azole-antimycotics, e.g., ketoconazole, itraconazole, voriconazole, or posaconazole, and HIV protease inhibitors, e.g., ritonavir.