Use of a Live Attenuated Vaccine as an Immune-based Preventive Against COVID-19-associated Sepsis

Inclusion Criteria: * 18-70 years of age * Employed as a HCW (hospital, outpatient clinic, private office or 1st responder (EMS) in the greater New Orleans region * Able to provide a signed and dated informed consent * Able to provide pre-randomized blood specimen Exclusion Criteria: * Any known MMR vaccine contraindication * Fever * Weakened resistance toward infections due to a disease in/of the immune system * Individuals receiving medical treatment that affects the immune response or other immunosuppressive therapy in the last year (see excluded medications). * Individuals with a congenital cellular immunodeficiency * Individuals with a malignancy involving bone marrow or lymphoid systems * Individuals with any serious underlying illness (such as malignancy). People with cardiovascular disease, hypertension, diabetes, and/or chronic respiratory disease are eligible if not immunocompromised (at the discretion of the ID Co-investigator) * Individuals with known or suspected HIV infection, even if asymptomatic or has normal immune function. (Due to the risk of disseminated MMR infection) * Individuals with an active skin disease such as eczema, dermatitis or psoriasis at or near the site of vaccination. A different site can be chosen if necessary * Pregnant or women who think they may test positive for pregnancy in this next month following MMR vaccine administration. * Individuals who have received a MMR or another live vaccine (i.e., Zostavax, nasal flu vaccine) within …