The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI

Inclusion Criteria: \- Exclusion Criteria: * Cardiac pacemaker or defibrillator implantation Intracranial metal device implantation * Other major systemic diseases, such as renal failure, heart failure, stroke, AMI/unstable angina, poorly controlled diabetes mellitus, poorly controlled hypertension * Alcohol or drug abuse * Moderate to severe dementia * Severe movement disorders * Imaging data is similar to a nuclear medical examination, exclusion criteria is any abnormality that may affect cognitive function as reflected in computer tomography or MRI records, such as hydrocephalus or encephalitis. Mild cortical atrophy is acceptable. * History of intracranial surgery including thalamotomy, pallidotomy, and/or deep brain stimulation * Major physical or neuropsychiatric disorders * Structural abnormalities that may cause dementia, such as cortical infarction, tumour, or subdural hematoma * Besides medication for Parkinson's Disease, taking other medication with substances that can pass through the blood-brain barrier * Besides medication for Parkinson's Disease, taking other medication for more than 10 years * Treatments or concurrent illnesses other than Alzheimer's Disease that could interfere with cognitive function * Meet the criteria for dementia (DSM-IV) * Head trauma with loss of consciousness greater than 10 minutes * Severe loss of sensation